401365 Healthcare Data for Decision Making Assignment Please answer all 4 questions. Record your answers in the template document provided and submit via Turnitin before 11:59pm on the due date. The marks allocated to each question are shown in the assignment. A total of 35 marks are available and this assignment is worth 35% of your overall grade.

Copying answers from other students, sharing answers with other students and writing answers in a group are all forms of cheating. Any student doing any of these will be reported for academic misconduct.

Question 1 [6 marks]
Free fatty acids (FFA) were measured in fasting blood sample of 13 non-insulin-dependent diabetic

men and 10 non-diabetic men. The results (in mmoI/L) were:

Diabetic

430 340 560 390 430 385 345 370 317 311 687 323 618 Non-diabetic:
445 265 493 265 410 274 296 219 286 250

1. a)  Determine if the FFA is different for diabetic men and non-diabetic men [4 marks]
2. b)  Write a brief summary of what the result show. [2 marks]

Question 2 [11 marks]

401365 Healthcare Data for Decision Making Assignment

Two types of aerosol, A and B were compared in asthmatic patients. 85 patients were included in a cross-over trial. Each patient used each aerosol for a period month, with the order of administration at random. For 19 patients their symptoms were better controlled while on aerosol A and for 36 whilst they were on aerosol B. 26 patients did well on both A and B and 9 failed to complete the trial.

1. a)  Draw a 2 by 2 table [2 marks]
2. b)  Is there any evidence of a difference in the effect between A and B? [7 marks]
3. c)  Write a brief summary of what the result show. [2 marks]

Question 3 [11 marks]

COVID-19 vaccine was tested in a randomised controlled trial in which 400,000 adults selected from the population were divided into two similar groups. Adults in one group were given the vaccine while those in the other group were given a placebo. At a later date the number of adults contracting COVID-19 in each group were determined.

In the vaccine group, there were 56 cases of COVID-19 out of 200,000 adults while in the placebo group, there were 142 cases of COVID-19 of the 200,000 adults.

1. a)  Draw a 2 by 2 table [2 marks]
2. b)  Carry out a significance test to compare the incidence of COVID-19 in the two groups [7

   marks]

3. c)  Write a brief report on your conclusion about the effectiveness of the COVID-19 vaccine. [2

   marks]

Question 4 [7 marks]

A study to determine haemoglobin due to the strength of medication categorised into 5 groups were conducted on 27 women aged 18-40 years. The table below displays the data and the relevant descriptive quantities.

Medication strength

401365 Healthcare Data for Decision Making Assignment

ABCDE

0.8 0.7 0.6 0.8 0.6 0.5 0.5 0.5

1.2 1.0 0.6 1.0 0.9 0.4 0.9 0.9 0.4 1.2 1.1 0.7

0.6 1.3 0.7 0.3 0.9 0.8
0.7

1. a)  Normality assumption was checked, and it was not normally distributed. Hence, determine if the five groups of medication strength have the same median haemoglobin level? [5 marks]
2. b)  Write a brief summary of what the result show. [2 marks]
3. 401365 Healthcare Data for Decision Making Assignment

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